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pentobarbital will lower the level or outcome of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Not known.pentobarbital raises effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Warning/Check. Coadministration of ifosfamide with CYP2B6 inducers might maximize metabolism of ifo